Prevalence of carbapenem-resistant gram-negative bacilli producing carbapenemase by modified carbapenem inactivation method in an educational hospital in Tehran

Introduction: Regarding the crucial role of geographic factors in different mechanisms underlying bacterial antibiotic resistance worldwide, it is necessary to design and conduct studies determine prevalence specific this phenomenon. Objectives: This study was performed assess carbapenem-resistant gram-negative bacilli which produce carbapenemase, Loghman Hakim hospital, Tehran. Patients Methods: In cross-sectional study, 300 samples from patients evaluated; 145 were identified as carbapenem-resistant. Carbapenemase enzyme production these assessed by modified carbapenem inactivation method (mCIM). Results: About 81% collected intensive care unit. terms sample type, most obtained trachea urine culture. Acinetobacter baumannii (43%) common strain. Klebsiella pneumoniae (38%) Pseudomonas aeruginosa (11%) ranked second third strains, respectively. Based on mCIM evaluation, 82% due presence carbapenemase showed no significant difference neither between both genders nor various types. However, among carbapenemase-resistant bacilli, significantly higher A. (92%) Escherichia coli (80%) also older than 50 years old. Conclusion: The findings present that half resistant carbapenem, enzyme. well strains.